作為現(xiàn)代科學的一個重要分支,生物統(tǒng)計和生物信息學運用統(tǒng)計、數(shù)學和計算機科學的方法研究生物及醫(yī)學問題。在《生物統(tǒng)計及生物信息學前沿(英文版)》中,收錄了15篇文章介紹生物統(tǒng)計和生物信息學中統(tǒng)計方法的最新進展。由于篇幅有限,著重介紹了高維數(shù)據(jù)分析方法及其應(yīng)用。和統(tǒng)計學的其他分支相比,高維數(shù)據(jù)分析方法及其應(yīng)用還處在相對初級階段,希望《生物統(tǒng)計及生物信息學前沿(英文版)》的出版能夠推動此方向的研究。
Preface to the USTC Alumnis Series
From the Editors Shuangge Ma & Yuedong Wang
Preface Shaw-Hwa Lo
Section I Statistical Genetics
Linkage Analysis with Mixed Sample of Affected Full and Half Sib Pairs in
the Presence of Uncertain Relationship
Wenquan Cui, Hong Zhang, Yaning ]Pang, Zhaohai Li
Sequential Importance Sampling with Resampling in Molecular Population
Genetics
Yuguo Chen
Multiple-trait Quantitative Trait Loci Mapping Using Stochastic Search Vari-
able Selection
Nan Lin
Section II Statistical Analysis of Microarray Data
Statistical Analysis of Microarray Time Course Gene Expression Data with
Functional Hierarchical Models
Fangxin Hong
A Nonparametric Method for the Conservative Estimation of the Proportion
of True Null Hypotheses
Yinglei Lai
Partial Consistent Normalization Methods of Microarray Data
Heng Peng
Variance Estimation for Gene-expression Microarray Data
Tiejun Tong, Yuedong Wang
Section III Computational Biology
A Study of Protein Subcellular Localization Prediction
Huanqing Feng, Wenlong Xu, Xianghua Zhang, Ao Li, Dan Xie, Minghui
Wang
Computational Methods for Biomolecular Sequence Comparison
Kun-Mao Chao, Tao Jiang
Statistical Learning on a Complex Metabolomic Dataset
Xiaodong Lin, Susan J. Siramonsy, Chris Beecher, Young Truong, S.
Stanley Young
A Flexible Statistical Model for Chromatin Sequences
Ji-Ping Wang, Liqun Xi
Section IV General Methodology
Some Advances in Finite Mixture Models
Jiahua Chen
Smoothing Spline ANOVA with Heterogeneous Variances and Application to
EEG Data
Wensheng Guo, Ming Dai
Kernel Estimation in Longitudinal Data with Outcome-related Observation
Times
Donglin Zeng, Daohai Yu
A Computable Bound for the Geometric Convergence Rate of the Lasso Gibbs
Sampler
Hui Zou
Brief Introduction of Authors